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We investigate molecular mechanisms and therapeutic strategies for frontotemporal dementia and amyotrophic lateral sclerosis at the UCL Institute of Neurology and the UK Dementia Research Institute at UCL.

Find out more on our research page.

News

Adrian and Alex both presenting at the International ALS Symposium in Basel

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We are excited to be presenting at the largest international conference on ALS. Alex will present our exciting new data on lipid dysregulation in ALS and Adrian on FTD/ALS modelling and therapeutics.

Congratulations to Rubika for publishing her paper on PR CLIP!

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Rubika collaborated with the Ule lab to identify the RNA transcripts bound by C9orf72 polyPR in cells. We hope this will be a useful resource for the field, all the data is freely available: https://www.life-science-alliance.org/content/6/9/e202201824 With co-first author Igor Ruiz de los Mozos they identified the GAAGA pentamer to be…

Ashling gives talk at the Gordon Research Symposium on ALS

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Ashling was selected to give a talk at the GRS on ALS in Les Diablerets in Switzerland in July 2023. She presented her exciting data on neuronal lipid homeostasis in C9orf72 FTD/ALS.

Alex presents to people with MND at MNDA EnCouRage

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Alex gave a short talk at the MNDA EnCouRage meeting in June 2023, an MND patient-facing meeting for ECRs hosted by the MNDA.  Thanks to the MNDA for putting on this insightful event. https://www.mndassociation.org/research/research/mnd-encourage-uk-2023

Congratulations to Liam for passing his PhD viva!

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Thanks to his examiners Linda Greensmith and Guillaume Hautbergue for interesting and helpful discussions

George wins poster prize at the CZI Neurodegeneration Challenge Network Annual Meeting 2023!

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George gave a brilliant flash talk and poster on identifying new regulators of plasma and lysosomal membrane repair with Jez Carlton’s lab – great work George!