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We investigate molecular mechanisms and therapeutic strategies for frontotemporal dementia and amyotrophic lateral sclerosis at the UCL Institute of Neurology and the UK Dementia Research Institute at UCL.

Find out more on our research page.

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A web and twitter resource providing jargon free updates for the whole FTD community

News

2nd European C9orf72 Meeting: Hosting in London Jan 30-31st

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We are looking forward to the 2nd European C9orf72 Meeting January 30-31st 2020. This year the meeting is hosted by the Isaacs lab at UCL!

New preview article in Neuron: Relax, Don’t RAN Translate It

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See our new preview in Neuron: Wilson K, Muralidharan B, Isaacs A. Relax, Don’t RAN Translate It. Neuron. December 2019. https://doi.org/10.1016/j.neuron.2019.11.014 This is a preview of the following article: https://doi.org/10.1016/j.neuron.2019.09.003

New Publication in acta neuropathalogica: Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.

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We are pleased to announce the publication of our paper in Acta Neuropathalogica: Gittings, LM, Boeynaems, S, Lightwood, D, Clargo, A, Topia, S, Nakayama, L, Troakes, C, Mann, DMA, Gitler, AD, Lashley, T, Isaacs, AM. Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR…

UK DRI: Connectome 2019 Event

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Several members of the lab attended the DRI Connectome event this year, with Adrian Isaacs presenting our current genetic therapy projects and Carmelo Milioto presenting a poster on our knock-in mouse model currently in development.