We are excited to be part of Fratta lab’s new paper: Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo…
Our new paper Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD (Moens et al.) is now published on Acta Neuropathologica March 2018, Volume 135, Issue 3, pp 445–457
Our latest paper showing G-quadruplex-binding small molecules reduce pathology in C9orf72 iPSC-neurons and Drosophila models is just out in EMBO Molecular Medicine – early online version can be found here
Our PI Dr Isaacs is giving a lecture at University of Edinburgh on 26th of September 2017 as part of UE Neuroscience Seminar. The talk is titled “C9orf72 FTD and ALS – Mechanisms and therapeutics” and will be given at Lecture Theatre A, Chancellors Building, 13:00.
Our lab head Dr Adrian Isaacs will be giving a talk on our C9orf72 work at the Alzheimer’s Association International Conference in London in July