See our new preview in Neuron: Wilson K, Muralidharan B, Isaacs A. Relax, Don’t RAN Translate It. Neuron. December 2019. https://doi.org/10.1016/j.neuron.2019.11.014 This is a preview of the following article: https://doi.org/10.1016/j.neuron.2019.09.003
New Publication in acta neuropathalogica: Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.
We are pleased to announce the publication of our paper in Acta Neuropathalogica: Gittings, LM, Boeynaems, S, Lightwood, D, Clargo, A, Topia, S, Nakayama, L, Troakes, C, Mann, DMA, Gitler, AD, Lashley, T, Isaacs, AM. Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR…
Several members of the lab attended the DRI Connectome event this year, with Adrian Isaacs presenting our current genetic therapy projects and Carmelo Milioto presenting a poster on our knock-in mouse model currently in development.
Just published in Nature Neuroscience, Teresa provided important in vivo confirmation in our C9orf72 repeat fly models that RPS25 is a regulator of C9orf72 RAN translation and toxicity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713615/
Several members of the lab met with HRH The Princess Royal during her visit to learn about the research being undertaken at the UK DRI, including three of our PhD students, Catherine Heffner, Benedikt Holbling, and Liam Kempthorne. The Princess also received several demonstrations including one from our very own…
New Publication in Acta Neuropathologica Comms: Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS
We are pleased to announce our article, in collaboration with Dr. Tammaryn Lashley of the UCL Brain Bank, published in Acta Neuropathalogica Communications: Gittings, LM, Foti, SC, Benson, BC, Gami-Patel, P, Isaacs, AM, Lashley, T. Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS.. Acta Neuropathol Commun….
New Publication in Acta Neuropathalogica: C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A
We are excited to announce our new article published in Acta Neuropathalogica: Moens, TG, Niccoli, T, Wilson, KM, Atilano, ML, Birsa, N, Gittings, LM, Holbling, BV, Dyson, MC, Thoeng, A, Neeves, J, Glaria, I, Yu, L, Bussmann, J, Storkebaum, E, Pardo, M, Choudhary, JS, Fratta, P, Partridge, L, Isaacs, AM….
We are happy to announce that Jack Humphrey has successfully defended his thesis and passed his PhD viva. Jack is now looking forward to starting his post-doc position in Mount Sinai, New York in 2019. Congratulations, Jack!
New Publication in Brain: Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown.
We are excited to announce our new article published in Brain: Clayton, EL, Milioto, C, Muralidharan, B, Norona, FE, Edgar, JR, Soriano, A, Jafar-Nejad, P, Rigo, F, Collinge, J, Isaacs, AM. Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown. Brain. 2018;141 (12):3428-3442. Please see our publication page…
Adrian gave his inaugural lecture to a packed auditorium on his Journey of Discovery in FTD and ALS. Adrian is now Professor of Neurodegenerative Disease at the Institute of Neurology at UCL! https://www.ucl.ac.uk/ion/news/2018/dec/queen-square-inaugural-lectures-december-2018