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Our News

Fresh Out The Lab

Congrats to Sally on the first paper from her PhD, just out in EMBO!

By Adrian IsaacsUncategorized

A nice collaboration with Alessandro Provenzani’s lab on small molecule regulators of C9orf72 RAN translation. Sally investigated their effect in iPSC-motor neurons derived from people with C9orf72 repeat expansions. Paper just out in EMBO Journal: https://www.embopress.org/doi/full/10.15252/embj.2020105026

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19/11/2021
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Alex just awarded a prestigious EMBO post-doctoral fellowship!

By Adrian IsaacsUncategorized
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29/06/2021
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Carmelo gives rapid-fire talk at the mechanistic insights into the pathophysiology of ALS meeting

By Isaacs LabUncategorized

This was a great meeting jointly organised by UK DRI’s Marc-David Ruepp, with ~300 attendees and many excellent speakers including Adrian

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28/05/2021
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Great work by Magda just published in eLife!

By Isaacs LabUncategorized

Our new paper shows that activation of insulin signalling reduces C9orf72 repeat toxicity in fly models and reduces DPR levels in flies and human cells. https://elifesciences.org/articles/58565

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19/03/2021
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Congrats to Anneleis and Idoia on their new paper

By Adrian IsaacsUncategorized

Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity. https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-020-01036-y

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09/11/2020
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Progranulin and TMEM106B: when two become wan

By Adrian IsaacsUncategorized

Check out our mini-review of three new papers showing that TMEM106B and progranulin double knockouts fare worse than single knockouts. https://pubmed.ncbi.nlm.nih.gov/32985120/

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05/10/2020
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Congrats to Jack on his new paper on FUS autoregulation and splicing

By Adrian IsaacsUncategorized

Jack´s new paper: FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention. Humphrey J, Birsa N, Milioto C, McLaughlin M, Ule AM, Robaldo D, Eberle AB, Kräuchi R, Bentham M, Brown AL, Jarvis S, Bodo C, Garone MG, Devoy A, Soraru G, Rosa A, Bozzoni I,…

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31/07/2020
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Congratulations to Bhavana for becoming an independent PI!

By Adrian IsaacsUncategorized

Good luck with setting up your new lab at the Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore, India. 

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31/03/2020
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Adrian presented at the Packard Centre for ALS Annual Symposium

By Adrian IsaacsUncategorized

Adrian presented our recent work on developing new C9orf72 knock-in models at the Packard Centre for ALS Annual Symposium in Baltimore March 2nd-3rd 2020.

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03/03/2020
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2nd European C9orf72 Meeting: Hosting in London Jan 30-31st

By Adrian IsaacsUncategorized

We are looking forward to the 2nd European C9orf72 Meeting January 30-31st 2020. This year the meeting is hosted by the Isaacs lab at UCL!

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14/01/2020
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