A nice collaboration with Alessandro Provenzani’s lab on small molecule regulators of C9orf72 RAN translation. Sally investigated their effect in iPSC-motor neurons derived from people with C9orf72 repeat expansions. Paper just out in EMBO Journal: https://www.embopress.org/doi/full/10.15252/embj.2020105026
This was a great meeting jointly organised by UK DRI’s Marc-David Ruepp, with ~300 attendees and many excellent speakers including Adrian
Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity. https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-020-01036-y
Jack´s new paper: FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention. Humphrey J, Birsa N, Milioto C, McLaughlin M, Ule AM, Robaldo D, Eberle AB, Kräuchi R, Bentham M, Brown AL, Jarvis S, Bodo C, Garone MG, Devoy A, Soraru G, Rosa A, Bozzoni I,…
Good luck with setting up your new lab at the Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore, India.
Adrian presented our recent work on developing new C9orf72 knock-in models at the Packard Centre for ALS Annual Symposium in Baltimore March 2nd-3rd 2020.
We are looking forward to the 2nd European C9orf72 Meeting January 30-31st 2020. This year the meeting is hosted by the Isaacs lab at UCL!