We are very happy to announce that Lauren Gittings has successfully defended her thesis and passed her PhD viva. Lauren will continue working in the Isaacs lab until starting a new post-doc position middle of 2019. Congratulations Dr. Gittings!
The first of it’s kind, a meeting of European scientists working on C9orf72 FTD/ALS co-organised by Adrian and Dieter Edbauer (DZNE, Munich), aiming to encourage new collaborations. This was a fantastic meeting with all speakers presenting unpublished data and it helped encourage the sharing of resources and new collaborations, significantly…
Several members of the lab participated in an ARUK funded Meet the Scientist public event at UCL. We very much enjoyed talking to members of the public about our research and showcasing our stem-cell derived neurons whilst explaining how they are being used in the fight against dementia in the…
Several members of the lab attended the first UK DRI Connectome event. Adrian and Teresa both gave talks as did Sarah Mizielinska, an Isaacs Lab alumnus who has recently opened her own lab at the UK DRI at King’s College London. This event allowed UK DRI groups to showcase their…
Adrian recently spoke at the 8th annual FTD-UK meeting in Manchester. This talk featured the latest work from the lab and how this can be used to inform potential therapeutics for C9orf72-linked FTD/ALS.
We have a new review article published in Nature Reviews Neurology:Balendra, R, Isaacs, AM. C9orf72-mediated ALS and FTD: multiple pathways to disease. Nat Rev Neurol. 2018;14 (9):544-558.
We are excited to be part of Fratta lab’s new paper: Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo…
An exciting next step for the Isaacs Lab as we move to the UK DRI hub at UCL. It is a privilege to be a part of this new venture aiming to provide novel insight and therapeutics for dementia patients backed by a £290M initial investment by UK charities and…
Congratulations to our PhD student Thomas Moens for passing his viva. Tom will be moving to Belgium to continue his research on ALS. We are very proud!
Our new paper Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD (Moens et al.) is now published on Acta Neuropathologica March 2018, Volume 135, Issue 3, pp 445–457