Adrian Isaacs

buy brahmi online I did my undergraduate studies in molecular biology and genetics at the University of Manchester. As part of those studies I spent one year working at the Mayo Clinic in Florida with John Hardy and Mike Hutton, where I was part of the team that discovered that mutations in MAPT cause frontotemporal dementia. This set me on the path to research into neurodegenerative diseases. I then did my PhD at Oxford University and my post-doctoral studies at Harvard Medical School before coming to UCL to start my research group.

Postdoctoral Research Associates

Teresa Niccoli

I completed my undergraduate degree in Natural Sciences at Cambridge University and did my PhD with Paul Nurse at Cancer Research UK, studying cell polarity and microtubule dynamics in yeast. I continued investigating cell polarity at the Gurdon Institute in Cambridge with Daniel St Johnston. I then joined Linda Partridge’s lab at UCL to work on Drosophila models of neurodegeneration before moving to Adrian Isaacs’ laboratory where I am investigating disease mechanisms in ALS/FTD using Drosophila disease models.

Katie Wilson

I carried out my undergraduate degree in Biology at York University, which included a year in industry placement, joining a team researching gene therapy for cystic fibrosis at Imperial College London.  Prior to joining the Isaacs group, I completed my PhD at York, researching the role of glycans in osteogenesis. My research aims are to utilize patient derived induced pluripotent stem cells to create human neuronal cultures. These cultures will then be analysed using longitudinal imaging to gain further understanding of the disease mechanism of C9orf72 ALS/FTD.

Carmelo Milioto

After graduating in Biotechnology at the University of Milan, I did my PhD in Neuroscience and Brain Technologies at the Italian Institute of Technology, Genova. As part of my PhD, I also spent 2 years at the Center for Integrative Biology, University of Trento. I completed my PhD project “Role of skeletal muscle in spinal and bulbar muscular atrophy: identification of pathogenetic pathways and new translational approaches” in April 2016. I then joined Adrian Isaacs’ laboratory at the UCL Institute of Neurology. My current research focus is to generate new knock-in mouse models of amyotrophic lateral sclerosis (ALS). These mouse models will be important to further investigate the disease mechanism of C9orf72 ALS/FTD.

Magda Atilano

I graduated from Universidade da Beira Interior in Portugal, specializing in biochemistry. I subsequently moved to ITQB/ Universidade Nova de Lisboa to investigate the mechanisms used by S. aureus to avoid innate immune recognition. Following my PhD, I joined Petros Ligoxygakis’ Lab at the University of Oxford where I investigate the role of innate immune signaling in gut homeostasis using Drosophila as model organism. I joined Linda Partridge’s Lab at UCL and in collaboration with Adrian Isaacs’ group I am studying the neurodegeneration disease mechanism’s associated with C9orf72 repeat expansions using the drosophila model.

Bhavana Muralidharan

I did my undergraduate training in Biotechnology from GGSIP University, Delhi, India. I completed my PhD from NCCS, Pune, India studying post-transcriptional mechanisms of gene regulation. Subsequently I switched to developmental neurobiology and joined Shubha Tole’s lab at TIFR, Mumbai, India investigating the molecular mechanisms of cortical neurogenesis in the developing mouse brain. I have joined Adrian Isaacs lab to gain a molecular understanding of the disease mechanisms of the C9orf72 mutation from neurons made from patient derived iPSC lines.

PhD Students

Annalisa Cavallini

I graduated in Pharmaceutical Chemistry and Technology from the University of Bologna, Italy, and then completed an industrial placement at Eli Lilly and Co, Windlesham, UK; I then joined Lilly and I am currently working as a Research Biologist. In 2012 I started a part-time PhD in the laboratory of Adrian Isaacs at the UCL Institute of Neurology, focusing on cell-based models of tau aggregation and propagation and the molecular mechanisms of tau transmission in tauopathies.

Jack Humphrey

I completed an undergraduate masters degree in Natural Sciences from UCL with the rather unwieldy title of “Brain, Behaviour & Cognition with Synthetic Organic Chemistry”. After a brief trip abroad in Giessen, Germany to study rat enteric neurons, I finished my degree with a project investigating Mendelian pain disorders using molecular and cell biology with John Wood. I’ve since switched from the wet lab to the dry as my PhD, co-supervised by Adrian Isaacs and Vincent Plagnol, uses computational tools to investigate changes at the RNA level in different models of neurodegenerative disease.

Lauren Gittings

I completed my undergraduate degree in Natural Sciences at the University of Bath, during which time I spent a placement year working on multidrug resistance proteins in a lab at St Jude Children’s Research Hospital in Memphis, USA. After graduating, I started on the Leonard Wolfson Neurodegenerative Diseases PhD programme at UCL and carried out a range of rotation projects investigating various aspects of neurodegeneration. These projects included work with induced pluripotent stem cells, electrophysiology and where to buy purim cookies Drosophila models. I am currently working under the supervision of Dr. Adrian Isaacs and Dr. Tammaryn Lashley at the Queen Square Brain Bank where I am using neuropathology to investigate the disease mechanism of C9orf72 ALS/FTD. 

Research Technicians

Annora Thoeng

I am a technician assisting in the study of C9orf72 mutation in FTD/ALS. I completed my undergraduate studies in medical science at University of Sydney, Australia. I’ve been working as a technician for over 6 years, specialising in molecular biology and protein work. Previous posts include Centenary Institute and Garvan Institute of Medical Research where I worked on various cancer research as well as Drosophila studies. I  relocated to London in July 2015 and joined the Isaacs lab at the UCL Institute of Neurology that October.

Idoia Glaria

I graduated in Biology at University of Navarra, Spain, and then completed MSc and PhD in Biotechnology at the Institute of Agrobiotechnology. During my PhD, I performed the isolation and characterization of Small Ruminant Lentivirus strains involved in highly pathogenic outbreaks, researching the role of cellular restriction factors, such as APOBEC3, in the elimination of the virus. I worked as Senior Technician for the Spanish National Research Council and then I joined Adrian Isaacs’ group. My research aim is to measure dipeptide repeat proteins in human samples and drosophila/iPSC derived neuron models as they are potential biomarkers of C9orf72 ALS/FTD disease progression.

Alumni

Thomas Moens

enter Current: Post-doctoral scientist VIB Leuven

I was a PhD student working under the supervision of Dr Adrian Isaacs and Professor Linda Partridge. My research focused on attempting to understand the processes that lead to neurodegeneration in patients with amyotrophic lateral sclerosis and/or frontotemporal dementia, using fruit flies as a model system. I completed my undergraduate degree in Biological Sciences at the University of Oxford in 2012. After that I moved to UCL, where I undertook a masters degree in Neuroscience, before joining UCL PhD programme in Clinical Neuroscience supported by the Brain Research Trust.

conocer gente via gps Javier Gilbert (MRes student – 2016)

site de rencontre super rencontre Current: Junior lecturer and researcher, ESPOL Ecuador

I graduated with honors in Biology from Escuela Superior Politécnica del Litoral, Ecuador (2014). During my undergraduate I collaborated as a Research student in Antarctica for a binational cooperation project (Ecuador-Chile), performing genetic biomarker discovery of Antarctic sea urchin ( buy inderal in australia S. neumayeri). I joined the lab as part of the project “Development of a biomarker for FTD and ALS caused by C9orf72 repeat expansion” and successfully obtained a MRes Translational Neurology at UCL.

Roberto Simone (Postdoctoral scientist – 2016)

follow link Current: Postdoctoral scientist, Department of Molecular Neuroscience, Institute of Neurology, UCL

My current research focus is on developing a small molecule-based therapeutic strategy to target the large intronic expansions present in individuals affected by C9-ALS-FTD. After graduating in Molecular Biology at the University “La Sapienza” of Rome under the supervision of Prof. Irene Bozzoni, I did my PhD in Functional Genomics, characterizing the transcriptional landscapes of mouse dopaminergic neurons. As part of these studies, I spent one year at RIKEN in Tokyo, where together with Piero Carninci and Charles Plessy, I contributed to develop nanoCAGE, a method to map and quantify transcription start sites genome-wide. During my previous postdoctoral experience I mainly focused on understanding mechanisms for human tau co- and post-transcriptional regulation.

Emma Clayton (Postdoctoral scientist – 2016)

see url Current: Postdoctoral scientist, Dept of Clinical & Experimental Epilepsy, Institute of Neurology, UCL

As an undergraduate I studied genetics at University College Cork, Ireland. After an internship at the Kennedy Space Centre, I moved to Scotland to pursue a Neuroscience PhD on synaptic vesicle trafficking. I moved to UCL in 2009, to focus on intracellular trafficking.  My work looked at the effect of mutation of the CHMP2B gene on the endolysosomal system in frontotemporal dementia.

Frances Norona (Technician – 2016)

http://werksmanjackson.com/?milihuos=edition-rencontre-lausanne-emile-zola&4a6=5f Current: Student at The Royal Veterinary College 

I studied Molecular and Cell Biology with an emphasis in Neurobiology at the University of California, Berkeley. I then did a two year stint in the Peace Corps delivering community health education in Albania. Returning to science, I worked in a neurobiology laboratory at the Ohio State University where I studied circadian rhythms. I have been working in Dr Adrian Isaacs’ laboratory as a research technician, assisting on both the C9orf72 and CHMP2B projects. In addition, I am currently pursuing a degree in veterinary medicine at the Royal Veterinary College.