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We investigate molecular mechanisms and therapeutic strategies for frontotemporal dementia and amyotrophic lateral sclerosis at the UCL Institute of Neurology and the UK Dementia Research Institute at UCL.

Find out more on our research page.

News

Our latest paper is out in Nature Neuroscience!

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We developed new polyGR and polyPR knock-in mice that developed features of ALS and surprisingly had a neuroprotective extracellular matrix response. An epic effort by lead author Carmelo and many lab members and collaborators including Elizabeth Fisher at UCL. Covered by Alzforum: https://www.alzforum.org/news/research-news/neuroprotective-extracellular-matrix-seen-c9orf72-alsftd-models and more info here: https://ukdri.ac.uk/news-and-events/protective-response-to-early-changes-in-als-and-ftd

Adrian and Alex both presenting at the International ALS Symposium in Basel

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We are excited to be presenting at the largest international conference on ALS. Alex will present our exciting new data on lipid dysregulation in ALS and Adrian on FTD/ALS modelling and therapeutics.

Congratulations to Ashling for passing her PhD viva!

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Congratulations to Rubika for publishing her paper on PR CLIP!

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Rubika collaborated with the Ule lab to identify the RNA transcripts bound by C9orf72 polyPR in cells. We hope this will be a useful resource for the field, all the data is freely available: https://www.life-science-alliance.org/content/6/9/e202201824 With co-first author Igor Ruiz de los Mozos they identified the GAAGA pentamer to be…

Ashling gives talk at the Gordon Research Symposium on ALS

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Ashling was selected to give a talk at the GRS on ALS in Les Diablerets in Switzerland in July 2023. She presented her exciting data on neuronal lipid homeostasis in C9orf72 FTD/ALS.

Alex presents to people with MND at MNDA EnCouRage

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Alex gave a short talk at the MNDA EnCouRage meeting in June 2023, an MND patient-facing meeting for ECRs hosted by the MNDA.  Thanks to the MNDA for putting on this insightful event. https://www.mndassociation.org/research/research/mnd-encourage-uk-2023