Alex gave a short talk at the MNDA EnCouRage meeting in June 2023, an MND patient-facing meeting for ECRs hosted by the MNDA. Thanks to the MNDA for putting on this insightful event. https://www.mndassociation.org/research/research/mnd-encourage-uk-2023
Thanks to his examiners Linda Greensmith and Guillaume Hautbergue for interesting and helpful discussions
George gave a brilliant flash talk and poster on identifying new regulators of plasma and lysosomal membrane repair with Jez Carlton’s lab – great work George!
Christina will be working on a gene therapy project for ALS/FTD. We are proud supporters of the In2research Programme: https://in2scienceuk.org/in2research/
We developed an ultra-sensitive Simoa-based immunoassay for detecting C9orf72 polyGP in CSF. In collaboration with Wave Life Sciences we validated the assay for clinical trial use and validated it using samples from the Genetic FTD Initiative. A great collaboration with Henrik Zetterberg, Amanda Heslegrave, Jon Rohrer and Wave.
A nice collaboration with Alessandro Provenzani’s lab on small molecule regulators of C9orf72 RAN translation. Sally investigated their effect in iPSC-motor neurons derived from people with C9orf72 repeat expansions. Paper just out in EMBO Journal: https://www.embopress.org/doi/full/10.15252/embj.2020105026
This was a great meeting jointly organised by UK DRI’s Marc-David Ruepp, with ~300 attendees and many excellent speakers including Adrian