The entire lab attended the annual DRI event in Harrogate, where we enjoyed engaging talks (including one by Alex), a variety of posters, and plenty of insightful discussions. It was a great opportunity to reconnect with familiar faces and meet new ones. Looking forward to next year!
In2Research summer placement student Aaliyah presented her research at the Royal Institution as part as the In2Research Celebration Event.
We developed new polyGR and polyPR knock-in mice that developed features of ALS and surprisingly had a neuroprotective extracellular matrix response. An epic effort by lead author Carmelo and many lab members and collaborators including Elizabeth Fisher at UCL. Covered by Alzforum: https://www.alzforum.org/news/research-news/neuroprotective-extracellular-matrix-seen-c9orf72-alsftd-models and more info here: https://ukdri.ac.uk/news-and-events/protective-response-to-early-changes-in-als-and-ftd
Adrian gave an update on our latest ALS research to the Packard Center Symposium in Baltimore
We are excited to be presenting at the largest international conference on ALS. Alex will present our exciting new data on lipid dysregulation in ALS and Adrian on FTD/ALS modelling and therapeutics.
Rubika collaborated with the Ule lab to identify the RNA transcripts bound by C9orf72 polyPR in cells. We hope this will be a useful resource for the field, all the data is freely available: https://www.life-science-alliance.org/content/6/9/e202201824 With co-first author Igor Ruiz de los Mozos they identified the GAAGA pentamer to be…