We developed new polyGR and polyPR knock-in mice that developed features of ALS and surprisingly had a neuroprotective extracellular matrix response. An epic effort by lead author Carmelo and many lab members and collaborators including Elizabeth Fisher at UCL. Covered by Alzforum: https://www.alzforum.org/news/research-news/neuroprotective-extracellular-matrix-seen-c9orf72-alsftd-models and more info here: https://ukdri.ac.uk/news-and-events/protective-response-to-early-changes-in-als-and-ftd