This was a great meeting jointly organised by UK DRI’s Marc-David Ruepp, with ~300 attendees and many excellent speakers including Adrian
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Our new paper shows that activation of insulin signalling reduces C9orf72 repeat toxicity in fly models and reduces DPR levels in flies and human cells. https://elifesciences.org/articles/58565
Just published in Nature Neuroscience, Teresa provided important in vivo confirmation in our C9orf72 repeat fly models that RPS25 is a regulator of C9orf72 RAN translation and toxicity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713615/
Several members of the lab met with HRH The Princess Royal during her visit to learn about the research being undertaken at the UK DRI, including three of our PhD students, Catherine Heffner, Benedikt Holbling, and Liam Kempthorne. The Princess also received several demonstrations including one from our very own…
We are pleased to announce our article, in collaboration with Dr. Tammaryn Lashley of the UCL Brain Bank, published in Acta Neuropathalogica Communications: Gittings, LM, Foti, SC, Benson, BC, Gami-Patel, P, Isaacs, AM, Lashley, T. Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS.. Acta Neuropathol Commun….
We are excited to announce our new article published in Acta Neuropathalogica: Moens, TG, Niccoli, T, Wilson, KM, Atilano, ML, Birsa, N, Gittings, LM, Holbling, BV, Dyson, MC, Thoeng, A, Neeves, J, Glaria, I, Yu, L, Bussmann, J, Storkebaum, E, Pardo, M, Choudhary, JS, Fratta, P, Partridge, L, Isaacs, AM….
Adrian gave his inaugural lecture to a packed auditorium on his Journey of Discovery in FTD and ALS. Adrian is now Professor of Neurodegenerative Disease at the Institute of Neurology at UCL! https://www.ucl.ac.uk/ion/news/2018/dec/queen-square-inaugural-lectures-december-2018
The first of it’s kind, a meeting of European scientists working on C9orf72 FTD/ALS co-organised by Adrian and Dieter Edbauer (DZNE, Munich), aiming to encourage new collaborations. This was a fantastic meeting with all speakers presenting unpublished data and it helped encourage the sharing of resources and new collaborations, significantly…
Several members of the lab participated in an ARUK funded Meet the Scientist public event at UCL. We very much enjoyed talking to members of the public about our research and showcasing our stem-cell derived neurons whilst explaining how they are being used in the fight against dementia in the…
Several members of the lab attended the first UK DRI Connectome event. Adrian and Teresa both gave talks as did Sarah Mizielinska, an Isaacs Lab alumnus who has recently opened her own lab at the UK DRI at King’s College London. This event allowed UK DRI groups to showcase their…