Our new paper shows that activation of insulin signalling reduces C9orf72 repeat toxicity in fly models and reduces DPR levels in flies and human cells. https://elifesciences.org/articles/58565
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Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity. https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-020-01036-y
Check out our mini-review of three new papers showing that TMEM106B and progranulin double knockouts fare worse than single knockouts. https://pubmed.ncbi.nlm.nih.gov/32985120/
Jack´s new paper: FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention. Humphrey J, Birsa N, Milioto C, McLaughlin M, Ule AM, Robaldo D, Eberle AB, Kräuchi R, Bentham M, Brown AL, Jarvis S, Bodo C, Garone MG, Devoy A, Soraru G, Rosa A, Bozzoni I,…
Good luck with setting up your new lab at the Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore, India.
Adrian presented our recent work on developing new C9orf72 knock-in models at the Packard Centre for ALS Annual Symposium in Baltimore March 2nd-3rd 2020.
We are looking forward to the 2nd European C9orf72 Meeting January 30-31st 2020. This year the meeting is hosted by the Isaacs lab at UCL!
See our new preview in Neuron: Wilson K, Muralidharan B, Isaacs A. Relax, Don’t RAN Translate It. Neuron. December 2019. https://doi.org/10.1016/j.neuron.2019.11.014 This is a preview of the following article: https://doi.org/10.1016/j.neuron.2019.09.003
We are pleased to announce the publication of our paper in Acta Neuropathalogica: Gittings, LM, Boeynaems, S, Lightwood, D, Clargo, A, Topia, S, Nakayama, L, Troakes, C, Mann, DMA, Gitler, AD, Lashley, T, Isaacs, AM. Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR…
Several members of the lab attended the DRI Connectome event this year, with Adrian Isaacs presenting our current genetic therapy projects and Carmelo Milioto presenting a poster on our knock-in mouse model currently in development.