Several members of the lab attended the first UK DRI Connectome event. Adrian and Teresa both gave talks as did Sarah Mizielinska, an Isaacs Lab alumnus who has recently opened her own lab at the UK DRI at King’s College London. This event allowed UK DRI groups to showcase their…
Adrian recently spoke at the 8th annual FTD-UK meeting in Manchester. This talk featured the latest work from the lab and how this can be used to inform potential therapeutics for C9orf72-linked FTD/ALS.
We have a new review article published in Nature Reviews Neurology:Balendra, R, Isaacs, AM. C9orf72-mediated ALS and FTD: multiple pathways to disease. Nat Rev Neurol. 2018;14 (9):544-558.
We are excited to be part of Fratta lab’s new paper: Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo…
An exciting next step for the Isaacs Lab as we move to the UK DRI hub at UCL. It is a privilege to be a part of this new venture aiming to provide novel insight and therapeutics for dementia patients backed by a £290M initial investment by UK charities and…
Congratulations to our PhD student Thomas Moens for passing his viva. Tom will be moving to Belgium to continue his research on ALS. We are very proud!
Our new paper Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD (Moens et al.) is now published on Acta Neuropathologica March 2018, Volume 135, Issue 3, pp 445–457
We are so proud to announce our latest PhD from the lab – Annalisa Cavillini.
Welcome to Sally Salomonsson who has just started an MRC-funded PhD with us to work on C9orf72
Our latest paper showing G-quadruplex-binding small molecules reduce pathology in C9orf72 iPSC-neurons and Drosophila models is just out in EMBO Molecular Medicine – early online version can be found here