Just published in Nature Neuroscience, Teresa provided important in vivo confirmation in our C9orf72 repeat fly models that RPS25 is a regulator of C9orf72 RAN translation and toxicity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713615/
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Several members of the lab met with HRH The Princess Royal during her visit to learn about the research being undertaken at the UK DRI, including three of our PhD students, Catherine Heffner, Benedikt Holbling, and Liam Kempthorne. The Princess also received several demonstrations including one from our very own…
We are pleased to announce our article, in collaboration with Dr. Tammaryn Lashley of the UCL Brain Bank, published in Acta Neuropathalogica Communications: Gittings, LM, Foti, SC, Benson, BC, Gami-Patel, P, Isaacs, AM, Lashley, T. Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS.. Acta Neuropathol Commun….
We are excited to announce our new article published in Acta Neuropathalogica: Moens, TG, Niccoli, T, Wilson, KM, Atilano, ML, Birsa, N, Gittings, LM, Holbling, BV, Dyson, MC, Thoeng, A, Neeves, J, Glaria, I, Yu, L, Bussmann, J, Storkebaum, E, Pardo, M, Choudhary, JS, Fratta, P, Partridge, L, Isaacs, AM….
We are happy to announce that Jack Humphrey has successfully defended his thesis and passed his PhD viva. Jack is now looking forward to starting his post-doc position in Mount Sinai, New York in 2019. Congratulations, Jack!
We are excited to announce our new article published in Brain: Clayton, EL, Milioto, C, Muralidharan, B, Norona, FE, Edgar, JR, Soriano, A, Jafar-Nejad, P, Rigo, F, Collinge, J, Isaacs, AM. Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown. Brain. 2018;141 (12):3428-3442. Please see our publication page…
Adrian gave his inaugural lecture to a packed auditorium on his Journey of Discovery in FTD and ALS. Adrian is now Professor of Neurodegenerative Disease at the Institute of Neurology at UCL! https://www.ucl.ac.uk/ion/news/2018/dec/queen-square-inaugural-lectures-december-2018
We are very happy to announce that Lauren Gittings has successfully defended her thesis and passed her PhD viva. Lauren will continue working in the Isaacs lab until starting a new post-doc position middle of 2019. Congratulations Dr. Gittings!
The first of it’s kind, a meeting of European scientists working on C9orf72 FTD/ALS co-organised by Adrian and Dieter Edbauer (DZNE, Munich), aiming to encourage new collaborations. This was a fantastic meeting with all speakers presenting unpublished data and it helped encourage the sharing of resources and new collaborations, significantly…
Several members of the lab participated in an ARUK funded Meet the Scientist public event at UCL. We very much enjoyed talking to members of the public about our research and showcasing our stem-cell derived neurons whilst explaining how they are being used in the fight against dementia in the…