We are excited to announce our new article published in Brain: Clayton, EL, Milioto, C, Muralidharan, B, Norona, FE, Edgar, JR, Soriano, A, Jafar-Nejad, P, Rigo, F, Collinge, J, Isaacs, AM. Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown. Brain. 2018;141 (12):3428-3442. Please see our publication page…
Adrian gave his inaugural lecture to a packed auditorium on his Journey of Discovery in FTD and ALS. Adrian is now Professor of Neurodegenerative Disease at the Institute of Neurology at UCL! https://www.ucl.ac.uk/ion/news/2018/dec/queen-square-inaugural-lectures-december-2018
We are very happy to announce that Lauren Gittings has successfully defended her thesis and passed her PhD viva. Lauren will continue working in the Isaacs lab until starting a new post-doc position middle of 2019. Congratulations Dr. Gittings!
The first of it’s kind, a meeting of European scientists working on C9orf72 FTD/ALS co-organised by Adrian and Dieter Edbauer (DZNE, Munich), aiming to encourage new collaborations. This was a fantastic meeting with all speakers presenting unpublished data and it helped encourage the sharing of resources and new collaborations, significantly…
Several members of the lab participated in an ARUK funded Meet the Scientist public event at UCL. We very much enjoyed talking to members of the public about our research and showcasing our stem-cell derived neurons whilst explaining how they are being used in the fight against dementia in the…
Several members of the lab attended the first UK DRI Connectome event. Adrian and Teresa both gave talks as did Sarah Mizielinska, an Isaacs Lab alumnus who has recently opened her own lab at the UK DRI at King’s College London. This event allowed UK DRI groups to showcase their…
Adrian recently spoke at the 8th annual FTD-UK meeting in Manchester. This talk featured the latest work from the lab and how this can be used to inform potential therapeutics for C9orf72-linked FTD/ALS.
We have a new review article published in Nature Reviews Neurology:Balendra, R, Isaacs, AM. C9orf72-mediated ALS and FTD: multiple pathways to disease. Nat Rev Neurol. 2018;14 (9):544-558.
We are excited to be part of Fratta lab’s new paper: Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo…
An exciting next step for the Isaacs Lab as we move to the UK DRI hub at UCL. It is a privilege to be a part of this new venture aiming to provide novel insight and therapeutics for dementia patients backed by a £290M initial investment by UK charities and…